beta-2 Microglobulin anticorps (C-Term)

N° du produit ABIN6991888

Cet anticorps Lapin Polyclonal détecte spécifiquement beta-2 Microglobulin dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour beta-2 Microglobulin anticorps (C-Term) (ABIN6991888)

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp beta-2 Microglobulin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-beta-2 Microglobulin anticorps

Épitope: C-Term

Specificité: B2M antibody is human reactive.

Purification: B2M Antibody is affinity chromatography purified via peptide column.

Immunogène: B2M antibody was raised against a 15 amino acid peptide near the carboxy terminus of human B2M. The immunogen is located within the last 50 amino acids of B2M.

Isotype: IgG

Information d'application

Indications d'application: B2M antibody can be used for detection of B2M by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: B2M Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: B2M antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur beta-2 Microglobulin

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Autre désignation: B2M

Sujet: B2M Antibody: Beta2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system (1,2). B2M is involved in the presentation of peptide antigens to the immune system and plays a critically important role in immune system function (3). It is expressed on nearly all nucleated cells and contains one Ig-like C1-type (immunoglobulin-like) domain (2,3). Mutations in the Beta 2-microglobulin gene can enhance the progression of malignant melanoma and osteoarthropathy (4,5).

Poids moléculaire: Predicted: 13 kDa

Observed: 12 kDa

ID gène: 567

NCBI Accession: NP_004039

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process